Trigemina, Inc. brings together some of the world’s foremost researchers in pain and migraine to help people without the use of opioids. We all want strong, safe pain therapy, and Trigemina will deliver it.

We are currently developing two new drugs that exploit newly discovered pathways for targeting the central and peripheral nervous systems, enabling vast new opportunities for treating conditions such as chronic migraine and other head pain, as well as whole-body pain. Our lead drug is currently in clinical stage development for high frequency migraine.

Not Just a Headache

What makes migraines different from regular headaches?

Migraine is a neurological disease characterized by debilitating head pain. This pain is frequently accompanied by visual disturbances, nausea, vomiting, dizziness, extreme sensitivity to sound, light, touch and smell, and tingling or numbness in the extremities or face. Chronic and high frequency episodic migraineurs experience many migraines every month.

Click on the infographic to learn about migraine’s impact in the United States. Similar metrics apply to the rest of the world on a larger scale.

High Frequency Migraine

High frequency migraine (HFM) refers to the combined conditions of chronic migraine and high frequency episodic migraine. These two debilitating conditions have a staggering impact on the lives of sufferers and their loved ones.

High Frequency Episodic Migraine

8 to 14 headaches per month

Chronic Migraine

15+ headaches per month

Millions Suffering

3.5% - 4.0% of population has HFM