Scientific Advisory Board

Martin Angst, MD

Co-Founder

Martin Angst holds an appointment as a professor of anesthesia at Stanford University School of Medicine and is the founder and director of the Human Pain Laboratory at Stanford University Medical School. He pursues three inter-related areas of interest: the identification of objective pain biomarkers, the early validation or rejection of novel analgesic interventions, and the improved characterization of opioid pharmacology including genetic and immune-modulating aspects. Preclinical and clinical trials completed by Dr. Angst have been sponsored by the National Institute of Health, the Defense Advanced Research Projects Agency and the pharmaceutical industry.

Dr. Angst has published over 50 peer-reviewed articles and has authored several book chapters. He serves as an expert consultant in clinical pharmacology to the biotechnical, pharmaceutical and legal industry. He received his MD degree from the University of Berne, Switzerland, in 1993 and completed his fellowship training in clinical pharmacology in 1996 at the Department of Anesthesia of Stanford University Medical School.


Professor Rami Burstein, PhD

Professor Rami Burstein, PhD, is a Professor of Anesthesia and Neuroscience at Harvard Medical School, Vice Chairman of Research in the Department of Anesthesia and Critical Care at Beth Israel Deaconess Medical Center, and Academic Director of the Harvard Medical Faculty Physician Comprehensive Headache Center. He holds positions on many major committees including the Red Book Committee at Harvard Medical School.

Dr. Burstein has twice received the prestigious Wolff Award for Excellence in Headache Research from The American Headache Society. He sits on the editorial board of Cephalalgia, Pain, and The Journal of Headache and Pain. He is also a regular reviewer for prestigious medical journals such as Nature and Science. His community service work includes regular meetings with headache support groups in the Boston area.

Dr. Burstein received his PhD at the University of Minnesota. He did his postdoctoral training at Massachusetts General Hospital, where he was a fellow in the Pain Physiology Lab.


David W. Dodick, MD, FRCP (C), FACP, FAHS

David W. Dodick, MD, FRCP (C), FACP, FAHS is Professor of Neurology at the Mayo Clinic in Arizona. He is the Program Director of the Mayo Clinic Neurology Residency Program and Headache Medicine Fellowship Program. He is the Medical Director of the Headache Program as well as the Sport Neurology and Concussion Program at Mayo Clinic in Arizona.

Dr. Dodick received a medical degree with distinction from Dalhousie University, in Halifax, Nova Scotia. He completed an internship and a neurology residency at the Mayo Clinic in Rochester, Minnesota, followed by fellowship training at the University of Toronto, in Ontario. Dr. Dodick is board certified by the Royal College of Physicians and Surgeons of Canada and the American Board of Psychiatry and Neurology (ABPN). He also holds United Council for Neurologic Subspecialties certification in headache medicine and ABPN certification in vascular neurology.

Dr. Dodick has authored more than 300 peer-reviewed publications and coauthored 8 books. He serves as Editor in Chief of Cephalalgia and is on the editorial board of several journals including The Neurologist and Lancet Neurology. He is a past-President of the American Headache Society, President of the American Migraine Foundation, and President-elect of the International Headache Society.


William Frey II, PhD

Co-Founder

William H. Frey II is director of the Alzheimer’s Research Center at Regions Hospital in St. Paul, MN; professor of pharmaceutics and oral biology and faculty member in neurology and neuroscience at the University of Minnesota; and a consultant to the pharmaceutical and biotechnology industry. His patents – owned by Novartis, Stanford University, the HealthPartners Research Foundation and others – target noninvasive delivery of therapeutic agents, including stem cells, to the brain and spinal cord for treating neurological disorders, psychiatric disorders and obesity. Dr. Frey’s non-invasive intranasal method for bypassing the blood-brain barrier to target CNS therapeutic agents to the brain while reducing systemic exposure and unwanted side effects has captured the interest of pharmaceutical companies and neuroscientists.

Dr. Frey has over 90 publications in scientific and medical journals, such as the Journal of Biological Chemistry, Proceedings of the National Academy of Sciences, and Brain Research. He earned a bachelor of arts degree in chemistry at Washington University in 1969 and PhD in biochemistry at Case Western Reserve University in 1975.


Professor Marek Gawel, MD

Professor Marek Gawel, MD, is currently Associate Professor of Medicine (Neurology) at the University of Toronto. He is on staff at Sunnybrook Health Sciences Centre and Women’s College Hospital and the Rouge Valley Health System.  He sat on the Professional Education Committee of the Heart and Stroke Foundation of Ontario from 1984 to 1996. Dr. Gawel has been involved in numerous clinical trials in headache, stroke, and ALS as well as being involved in research in cluster headache. He was the chairman of the 1995 International Headache Society Congress held in Toronto. He has been Vice President of the Migraine Association of Canada. He is past President of the Canadian Headache Society and currently President of Headache Network Canada (http://www.headachenetwork.ca/) a web based resource for patients.  Dr. Gawel has authored 46 publications in migraine and is a co-author of the Guidelines for the Diagnosis and Management of Migraine in Clinical Practice.

Dr. Gawel graduated in Medicine from Cambridge University in 1971. After internship he did residence in neurosurgery, medicine, and neurology in Cambridge and Vancouver.  In 1975 he joined Charing Cross Hospital as a research fellow in Neurology and subsequently became a lecturer in Neurology. While there he worked at the Princess Margaret Headache Clinic. He is a winner of the Harold Wolff award.


Professor Jon D. Levine, MD, PhD

Professor Jon D. Levine, MD, PhD, Division of Neurosciences, UCSF, is a leading researcher in pain.

Dr. Levine’s research interests are in the area of pain and analgesia. He has been the recipient of several academic awards including: Young Investigator of the International

Association of Pain, American Society for Clinical Investigation, Association of Academic Professors, Guest Investigator in the ARC Muscle Mechanisms Laboratory (Oxford University), Chancellor’s Commendation for Research Excellence (University of California, San Francisco), Hartford foundation fellow, Most Important New Research in Rheumatic Diseases (NIH Annual Report to Congress), Frederick J. Kerr award of the American Pain Society and Rita Allen Foundation fellow. He has published over 400 basic science and clinical articles in this area, funded by the National Institutes of Health.

The areas of Dr. Levine’s research include elucidation of the transducers, second messenger systems and ionic channel mediating inflammatory, neuropathic and chronic widespread pain syndromes, the role of neuroimmune mechanisms in pain and inflammation, the mechanism of placebo analgesia, and sex differences in pain and analgesia.

Dr. Levine received a bachelor’s degree in biophysics from the University of Michigan (1966), a PhD in neuroscience from Yale University (1972), and an MD degree from the University of California at San Francisco (1978). He trained in Rheumatology and Clinical Immunology (under Jack Stobo), and in Clinical Pharmacology and Experimental Therapeutics (under Henry Bourne) (UCSF, 1983). He has been on the faculty at UCSF since and has been a Professor (Medicine, Oral and Maxillofacial Surgery and Neuroscience) since 1993.


Richard B. Lipton, MD

Richard B. Lipton, M.D., is the Edwin S. Lowe Professor and Vice Chair of Neurology, Professor of Epidemiology and Population Health and Professor of Psychiatry and Behavioral Sciences at the Albert Einstein College of Medicine. Dr. Lipton earned his medical degree at the University of Chicago Pritzker School of Medicine. After a medical internship at Northwestern Memorial Hospital, he completed his neurology residency and clinical neurophysiology fellowship at the Albert Einstein College of Medicine. He also completed a fellowship in neuroepidemiology at Columbia University. He is a diplomate of the American Board of Psychiatry and Neurology and a fellow of the American Academy of Neurology.
His research focuses on cognitive aging, Alzheimer’s disease and migraine headaches. He is the Principal Investigator of the Einstein Aging Study, an NIH funded Program Project, and several R01s.  His research focuses on risk factors and biomarkers of cognitive decline and Alzheimer’s disease. His recent studies examine cognitive aging across the lifespan with an emphasis on the effects of pain and stress on brain function.

His headache research focuses on the epidemiology of migraine and on clinical trials.  His epidemiologic studies have evaluated trigger factors for headache attacks and risk factors for headache progression. Dr. Lipton has published more than 500 original articles, many with trainees.  He is a 3 time winner of the H.G. Wolff Award for excellence in headache research from the American Headache Society and the Enrico Greppi award from the European Headache Federation.  Dr. Lipton is co-Director of the Montefiore Headache Center, an interdisciplinary subspecialty center focused on headache, patient care, research and education.

Dr. Lipton holds leadership positions in several professional societies. He is a Past-President of the American Headache Society (AHS).  He serves on the editorial boards of several journals, including Neurology. He has written 11 books. Dr. Lipton enjoys mentoring medical students, residents, PhD students and fellows.  Over the last decade he has mentored 7 CRTP students and 6 K-award recipients. He has received both the CRTP Mentor of the Year Award and the Einstein Faculty Mentoring Award.


Professor Fumihiko Sakai, MD

Professor Fumihiko Sakai, MD, is Professor at Saitama Medical University and is Director, Saitama International Headache Center, Saitama, Japan. In 1978 and 1979, he received the prestigious 13th and 14th Harold G. Wolff award from American Headache Society.  From 1997-2009 he was Professor and Chairman of Medicine (Neurology), at Kitasato University, School of Medicine.  He is the President and Director on the Board of the Japanese Headache Society, a Board Member of the American Headache Society, past President & Honorary Life Member of the International Headache Society and the Past Board Member & Honorary Member of the Societas Neurologica Japonica.

Dr. Sakai obtained his medical degree from Keio University and was a research fellow at the department of neurology of Baylor College of Medicine, Houston, U.S.A. and clinical fellow at the Keio University Hospital in Japan.


Stephen D. Silberstein, MD

Professor Stephen D. Silberstein, MD, is Professor of Neurology and Director of the Jefferson Headache Center at Thomas Jefferson University, and a leading expert in migraine. He is a Fellow of the American College of Physicians, the American Academy of Neurology, The American Neurological Association, and the American Headache Society. He has served the American Headache Society as President, Treasurer, and Board of Directors member. He has served on the Publications, Scientific, and Education Committees of the American Headache Society and was Co-chairman of the Annual Scientific Meeting. He is current chair of the guidelines committee of the American Headache Society. Dr. Silberstein is an active member of the American Academy of Neurology and was Co-director of the national and international Headache Guideline Project, in cooperation with the Agency for Health Care Policy and Research. He was the Chairman of the International Headache Society meeting in Philadelphia in 2009. He was Chairman of the headache research group of the World Federation of Neurology.

Dr. Silberstein received his medical degree from the University of Pennsylvania. He then completed a medical internship and junior residency at the Hospital of the University of Pennsylvania. After completing a fellowship in neurology at the National Hospital for Nervous Diseases in London, Dr. Silberstein served as a Pharmacology Research Associate in the Toxicology Laboratory of Clinical Science at the National Institutes of Mental Health, and completed a neurology residency at the Hospital of the University of Pennsylvania.

Dr. Silberstein is the Senior Editor of the 8th edition of Wolff’s Headache and Other Head Pain, Associate Editor of Cephalalgia and CNS Drugs, and a present or prior member of the Editorial Board of Headache; Cephalalgia; Acta Neurologica Scandinavica; Journal of Neurology, Neurosurgery & Psychiatry; and Topics in Pain Management. He is an ad hoc reviewer for many publications, including The New England Journal of Medicine; Brain, The Lancet, JAMA, Mayo Clinic Proceedings, Annals of Neurology, and Neurology.


Takao Takeshima, MD, PhD

Takao Takeshima, MD, PhD, is Deputy Director, Tominaga Hospital, Kyoto and is a Professor of Neurology of Kyoto University.  He has published widely on migraine and is considered one of the leading headache researchers and clinicians in Japan.